This collection is primarily correspondence and also notes on experiments concerning the cytology research of Lewis and his wife, Dr. Margaret Reed Lewis, at Johns Hopkins University, Carnegie Institution of Washington, and finally at the Wistar Institute of Anatomy and Biology in Philadelphia. There is significant material relating to his professional society activity in the American Association of Anatomists (President, 1934-1936) and the International Society for Experimental Cytology.

A pathologist and cancer specialist, James B. Murphy (1884-1950) spent most of career associated with the Rockefeller Institute (1911-1950) investigating the role of lymphocytes in tuberculosis, x-ray mutagenesis, and the nature of malignant tumors in fowls. The Murphy Papers contains professional correspondence and research notes relating to James B. Murphy's cancer research at the Rockefeller, and information on several of the organizations to which he contributed or belonged, including the American Association for Cancer Research; American Bureau for Medical Aid to China; American Cancer Society; Bar Harbor Medical and Surgical Hospital; Roscoe B. Jackson Memorial Laboratory; Memorial Hospital for the Treatment of Cancer (New York City, ca. 1932-1950); National Advisory Cancer Council; and the New York Academy of Medicine (1923-1950). Murphy helped to develop mobile laboratories for hospitals in France during World War I.